PUBLICATIONS (LAST 5 YEARS)

2020

42. Viloria K, Nasteska D, Briant LJB, Heising S, Larner DP, Fine NHF, Ashford FB, da Silva Xavier G, Ramos MJ, Hasib A, Cuozzo F, Manning Fox JE, MacDonald PE, Akerman I, Lavery GG, Flaxman C, Morgan NG, Richardson SJ, Hewison M, Hodson DJ. Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion. Cell Rep. 2020 Jun 16;31(11):107761. doi: 10.1016/j.celrep.2020.107761. PMID: 32553153; PMCID: PMC7302426.

41. Kemkem Y, Nasteska D, de Bray A, Bargi-Souza P, Peliciari-Garcia RA, Guillou A, Mollard P, Hodson DJ, Schaeffer M. Maternal hypothyroidism in mice influences glucose metabolism in adult offspring. Diabetologia. 2020 May 30;. doi: 10.1007/s00125-020-05172-x. [Epub ahead of print] PubMed PMID: 32472193.

40. Pickford P, Lucey M, Fang Z, Bitsi S, de la Serna JB, Broichhagen J, Hodson DJ, Minnion J, Rutter GA, Bloom SR, Tomas A, Jones B. Signalling, trafficking and glucoregulatory properties of glucagon-like peptide-1 receptor agonists exendin-4 and lixisenatide. Br J Pharmacol. 2020 May 20;. doi: 10.1111/bph.15134. [Epub ahead of print] PubMed PMID: 32436216.

39. Carrat GR, Haythorne E, Tomas A, Haataja L, Müller A, Arvan P, Piunti A, Cheng K, Huang M, Pullen TJ, Georgiadou E, Stylianides T, Amirruddin NS, Salem V, Distaso W, Cakebread A, Heesom KJ, Lewis PA, Hodson DJ, Briant LJ, Fung ACH, Sessions RB, Alpy F, Kong APS, Benke PI, Torta F, Keong Teo AK, Leclerc I, Solimena M, Wigley DB, Rutter GA. The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis. Mol Metab. 2020 May 13;:101015. doi: 10.1016/j.molmet.2020.101015. [Epub ahead of print] PubMed PMID: 32416313.

 

38. Seabright AP, Fine NHF, Barlow JP, Lord SO, Musa I, Gray A, Bryant JA, Banzhaf M, Lavery GG, Hardie DG, Hodson DJ, Philp A, Lai YC. AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1-Parkin independent manner. FASEB J. 2020 May;34(5):6284-6301. doi: 10.1096/fj.201903051R. Epub 2020 Mar 22. PubMed PMID: 32201986; PubMed Central PMCID: PMC7212019.

37. Hodson DJ, Rorsman P. A Variation on the Theme: SGLT2 Inhibition and Glucagon Secretion in Human Islets. Diabetes. 2020 May;69(5):864-866. doi: 10.2337/dbi19-0035. PubMed PMID: 32312904; PubMed Central PMCID: PMC7171971.

36. Fang Z, Chen S, Pickford P, Broichhagen J, Hodson DJ, Corrêa IR Jr, Kumar S, Görlitz F, Dunsby C, French PMW, Rutter GA, Tan T, Bloom SR, Tomas A, Jones B. The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists. ACS Pharmacol Transl Sci. 2020 Mar 17;3(2):345-360. doi: 10.1021/acsptsci.0c00022. PMID: 32296773; PMCID: PMC7155199.

35. Sayers SR, Beavil RL, Fine NHF, Huang GC, Choudhary P, Pacholarz KJ, Barran PE, Butterworth S, Mills CE, Cruickshank JK, Silvestre MP, Poppitt SD, McGill AT, Lavery GG, Hodson DJ, Caton PW. Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes. Diabetologia. 2020 Feb;63(2):313-323. doi: 10.1007/s00125-019-05029-y. Epub 2019 Nov 15. PubMed PMID: 31732790; PubMed Central PMCID: PMC6946736.

 

34. Nasteska D, Hodson DJ. GPR119 Agonism Revisited: A Novel Target for Increasing β-Cell Mass? Endocrinology. 2020 Feb 1;161(2):bqz018. doi: 10.1210/endocr/bqz018. PMID: 32053720.

33. Ast J, Arvaniti A, Fine NHF, Nasteska D, Ashford FB, Stamataki Z, Koszegi Z, Bacon A, Jones BJ, Lucey MA, Sasaki S, Brierley DI, Hastoy B, Tomas A, D'Agostino G, Reimann F, Lynn FC, Reissaus CA, Linnemann AK, D'Este E, Calebiro D, Trapp S, Johnsson K, Podewin T, Broichhagen J, Hodson DJ. Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics. Nat Commun. 2020 Jan 24;11(1):467. doi: 10.1038/s41467-020-14309-w. PMID: 31980626; PMCID: PMC6981144.

2019

32. Sayers SR, Beavil RL, Fine NHF, Huang GC, Choudhary P, Pacholarz KJ, Barran PE, Butterworth S, Mills CE, Cruickshank JK, Silvestre MP, Poppitt SD, McGill AT, Lavery GG, Hodson DJ, Caton PW. Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes. Diabetologia. 2019 Nov 15. doi: 10.1007/s00125-019-05029-y. [Epub ahead of print] PubMed PMID: 31732790.

31. Nasteska D, Viloria K, Everett L, Hodson DJ. Informing β-cell regeneration strategies using studies of heterogeneity. Mol Metab. 2019 Sep;27S:S49-S59. doi: 10.1016/j.molmet.2019.06.004. Review. PubMed Central PMID: 31500831

 

30. Thompson RJ, Fletcher A, Brookes K, Nieto H, Alshahrani MM, Mueller JW, Fine NH, Hodson DJ, Boelaert K, Read ML, Smith VE, McCabe CJ. Dimerization of the sodium/iodide symporter (NIS). Thyroid. 2019 Jul 16;. doi: 10.1089/thy.2019.0034. PubMed  Central PMID: 31310151.

 

29. O'Reilly MW, Westgate CS, Hornby C, Botfield H, Taylor AE, Markey K, Mitchell JL, Scotton WJ, Mollan SP, Yiangou A, Jenkinson C, Gilligan LC, Sherlock M, Gibney J, Tomlinson JW, Lavery GG, Hodson DJ, Arlt W, Sinclair AJ. A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics. JCI Insight.2019 Mar 21;4(6). doi: 10.1172/jci.insight.125348. eCollection 2019 Mar 21. PubMed PMID: 30753168; PubMed Central PMCID: PMC6483000.

 

28. Yip SH, Romanò N, Gustafson P, Hodson DJ, Williams EJ, Kokay IC, Martin AO, Mollard P, Grattan DR, Bunn SJ. Elevated Prolactin during Pregnancy Drives a Phenotypic Switch in Mouse Hypothalamic Dopaminergic Neurons. Cell Rep. 2019 Feb 12;26(7):1787-1799.e5. doi: 10.1016/j.celrep.2019.01.067. PubMed PMID: 30759390.

2018

27. Frank JA, Broichhagen J, Yushchenko DA, Trauner D, Schultz C, Hodson DJ. Optical tools for understanding the complexity of β-cell signalling and insulin release. Nat Rev Endocrinol. 2018 Dec;14(12):721-737. doi: 10.1038/s41574-018-0105-2. Review. PubMed PMID: 30356209.

 

26. Hodson DJ. A Niche Mechanism for β-Cell Regeneration in Type 1 Diabetes. Bioessays. 2018 Nov;40(11):e1800177. doi: 10.1002/bies.201800177. Epub 2018 Oct 9. PubMed PMID: 30298934.

 

25. Benninger RKP, Dorrell C, Hodson DJ, Rutter GA. The Impact of Pancreatic Beta Cell Heterogeneity on Type 1 Diabetes Pathogenesis. Curr Diab Rep. 2018 Sep 24;18(11):112. doi: 10.1007/s11892-018-1085-2. Review. PubMed PMID: 30251179; PubMed Central PMCID: PMC6153573.

 

24. Fehrentz T, Huber FME, Hartrampf N, Bruegmann T, Frank JA, Fine NHF, Malan D, Danzl JG, Tikhonov DB, Sumser M, Sasse P, Hodson DJ, Zhorov BS, Klöcker N, Trauner D. Optical control of L-type Ca2+ channels using a diltiazem photoswitch. Nat Chem Biol. 2018 Aug;14(8):764-767. doi: 10.1038/s41589-018-0090-8. Epub 2018 Jul 16. PubMed PMID: 30013061.

 

23. Nasteska D, Hodson DJ. The role of beta cell heterogeneity in islet function and insulin release. J Mol Endocrinol. 2018 Jul;61(1):R43-R60. doi: 10.1530/JME-18-0011. Epub 2018 Apr 16. Review. PubMed PMID: 29661799; PubMed Central PMCID: PMC5976077.

 

22. Navarro G, Allard C, Morford JJ, Xu W, Liu S, Molinas AJ, Butcher SM, Fine NH, Blandino-Rosano M, Sure VN, Yu S, Zhang R, Münzberg H, Jacobson DA, Katakam PV, Hodson DJ, Bernal-Mizrachi E, Zsombok A, Mauvais-Jarvis F. Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes. JCI Insight. 2018 Jun 21;3(12). doi: 10.1172/jci.insight.98607. eCollection 2018 Jun 21. PubMed PMID: 29925687; PubMed Central PMCID: PMC6124401.

 

21. da Silva Xavier G, Hodson DJ. Mouse models of peripheral metabolic disease. Best Pract Res Clin Endocrinol Metab. 2018 Jun;32(3):299-315. doi: 10.1016/j.beem.2018.03.009. Epub 2018 Mar 31. Review. PubMed PMID: 29779583.

 

20. Janjuha S, Singh SP, Tsakmaki A, Mousavy Gharavy SN, Murawala P, Konantz J, Birke S, Hodson DJ, Rutter GA, Bewick GA, Ninov N. Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish. Elife.2018 Apr 6;7. doi: 10.7554/eLife.32965. PubMed PMID: 29624168; PubMed Central PMCID: PMC5943033.

 

19. Benninger RKP, Hodson DJ. New Understanding of β-Cell Heterogeneity and In Situ Islet Function. Diabetes. 2018 Apr;67(4):537-547. doi: 10.2337/dbi17-0040. PubMed PMID: 29559510; PubMed Central PMCID: PMC5860861.

 

18. Rutter GA, Hodson DJ. Author Correction: Beta cell connectivity in pancreatic islets: a type 2 diabetes target?. Cell Mol Life Sci. 2018 Apr;75(7):1303-1305. doi: 10.1007/s00018-018-2767-2. PubMed PMID: 29450573.

 

17. Hollinshead KER, Munford H, Eales KL, Bardella C, Li C, Escribano-Gonzalez C, Thakker A, Nonnenmacher Y, Kluckova K, Jeeves M, Murren R, Cuozzo F, Ye D, Laurenti G, Zhu W, Hiller K, Hodson DJ, Hua W, Tomlinson IP, Ludwig C, Mao Y, Tennant DA. Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis. Cell Rep. 2018 Mar 20;22(12):3107-3114. doi: 10.1016/j.celrep.2018.02.084. PubMed PMID: 29562167; PubMed Central PMCID: PMC5883319.

 

16. Podewin T, Ast J, Broichhagen J, Fine NHF, Nasteska D, Leippe P, Gailer M, Buenaventura T, Kanda N, Jones BJ, M'Kadmi C, Baneres JL, Marie J, Tomas A, Trauner D, Hoffmann-Röder A, Hodson DJ. Conditional and Reversible Activation of Class A and B G Protein-Coupled Receptors Using Tethered Pharmacology. ACS Cent Sci. 2018 Feb 28;4(2):166-179. doi: 10.1021/acscentsci.7b00237. Epub 2018 Jan 16. PubMed PMID: 29532016; PubMed Central PMCID: PMC5832994.

2017

15. Fine NHF, Doig CL, Elhassan YS, Vierra NC, Marchetti P, Bugliani M, Nano R, Piemonti L, Rutter GA, Jacobson DA, Lavery GG, Hodson DJ. Glucocorticoids Reprogram β-Cell Signaling to Preserve Insulin Secretion. Diabetes. 2018 Feb;67(2):278-290. doi: 10.2337/db16-1356. Epub 2017 Dec 4. PubMed PMID: 29203512; PubMed Central PMCID: PMC5780059.

 

14. Frank JA, Yushchenko DA, Fine NHF, Duca M, Citir M, Broichhagen J, Hodson DJ, Schultz C, Trauner D. Optical control of GPR40 signalling in pancreatic β-cells. Chem Sci. 2017 Nov 1;8(11):7604-7610. doi: 10.1039/c7sc01475a. Epub 2017 Aug 30. PubMed PMID: 29568424; PubMed Central PMCID: PMC5848828.

 

13. Rutter GA, Hodson DJ, Chabosseau P, Haythorne E, Pullen TJ, Leclerc I. Local and regional control of calcium dynamics in the pancreatic islet. Diabetes Obes Metab. 2017 Sep;19 Suppl 1:30-41. doi: 10.1111/dom.12990. Review. PubMed PMID: 28466490.

 

12. Botfield HF, Uldall MS, Westgate CSJ, Mitchell JL, Hagen SM, Gonzalez AM, Hodson DJ, Jensen RH, Sinclair AJ. A glucagon-like peptide-1 receptor agonist reduces intracranial pressure in a rat model of hydrocephalus. Sci Transl Med.2017 Aug 23;9(404). doi: 10.1126/scitranslmed.aan0972. PubMed PMID: 28835515.

 

11. Cegla J, Jones BJ, Gardiner JV, Hodson DJ, Marjot T, McGlone ER, Tan TM, Bloom SR. RAMP2 Influences Glucagon Receptor Pharmacology via Trafficking and Signaling. Endocrinology. 2017 Aug 1;158(8):2680-2693. doi: 10.1210/en.2016-1755. PubMed PMID: 28586439; PubMed Central PMCID: PMC5551549.

 

10. Jones BJ, Scopelliti R, Tomas A, Bloom SR, Hodson DJ, Broichhagen J. Potent Prearranged Positive Allosteric Modulators of the Glucagon-like Peptide-1 Receptor. ChemistryOpen. 2017 Aug;6(4):501-505. doi: 10.1002/open.201700062. eCollection 2017 Aug. PubMed PMID: 28794944; PubMed Central PMCID: PMC5542757.

 

9. Podewin T, Broichhagen J, Frost C, Groneberg D, Ast J, Meyer-Berg H, Fine NHF, Friebe A, Zacharias M, Hodson DJ, Trauner D, Hoffmann-Röder A. Optical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormone. Chem Sci. 2017 Jun 1;8(6):4644-4653. doi: 10.1039/c6sc05044a. Epub 2017 Apr 19. PubMed PMID: 28626572; PubMed Central PMCID: PMC5471452.

 

8. Mitchell RK, Nguyen-Tu MS, Chabosseau P, Callingham RM, Pullen TJ, Cheung R, Leclerc I, Hodson DJ, Rutter GA. The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca2+ dynamics in adult mice. J Biol Chem. 2017 May 26;292(21):8892-8906. doi: 10.1074/jbc.M117.784629. Epub 2017 Apr 4. PubMed PMID: 28377501; PubMed Central PMCID: PMC5448123.

 

7. Le Tissier P, Campos P, Lafont C, Romanò N, Hodson DJ, Mollard P. An updated view of hypothalamic-vascular-pituitary unit function and plasticity. Nat Rev Endocrinol. 2017 May;13(5):257-267. doi: 10.1038/nrendo.2016.193. Epub 2016 Dec 9. Review. PubMed PMID: 27934864.

 

6. Mehta ZB, Johnston NR, Nguyen-Tu MS, Broichhagen J, Schultz P, Larner DP, Leclerc I, Trauner D, Rutter GA, Hodson DJ.Remote control of glucose homeostasis in vivo using photopharmacology. Sci Rep. 2017 Mar 22;7(1):291. doi: 10.1038/s41598-017-00397-0. PubMed PMID: 28331198; PubMed Central PMCID: PMC5428208.

 

5. Romanò N, Guillou A, Hodson DJ, Martin AO, Mollard P. Multiple-scale neuroendocrine signals connect brain and pituitary hormone rhythms. Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2379-2382. doi: 10.1073/pnas.1616864114. Epub 2017 Feb 13. PubMed PMID: 28193889; PubMed Central PMCID: PMC533854

2016

4. Johnston NR, Mitchell RK, Haythorne E, Pessoa MP, Semplici F, Ferrer J, Piemonti L, Marchetti P, Bugliani M, Bosco D, Berishvili E, Duncanson P, Watkinson M, Broichhagen J, Trauner D, Rutter GA, Hodson DJ. Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose. Cell Metab. 2016 Sep 13;24(3):389-401. doi: 10.1016/j.cmet.2016.06.020. Epub 2016 Jul 21. PubMed PMID: 27452146; PubMed Central PMCID: PMC5031557.

 

3. Frank JA, Yushchenko DA, Hodson DJ, Lipstein N, Nagpal J, Rutter GA, Rhee JS, Gottschalk A, Brose N, Schultz C, Trauner D. Photoswitchable diacylglycerols enable optical control of protein kinase C. Nat Chem Biol. 2016 Sep;12(9):755-62. doi: 10.1038/nchembio.2141. Epub 2016 Jul 25. PubMed PMID: 27454932; PubMed Central PMCID: PMC6101201.

 

2. Broichhagen J, Johnston NR, von Ohlen Y, Meyer-Berg H, Jones BJ, Bloom SR, Rutter GA, Trauner D, Hodson DJ.Allosteric Optical Control of a Class B G-Protein-Coupled Receptor. Angew Chem Int Ed Engl. 2016 May 4;55(19):5865-8. doi: 10.1002/anie.201600957. Epub 2016 Apr 5. PubMed PMID: 27059784; PubMed Central PMCID: PMC5031193.

 

1. Osterstock G, Mitutsova V, Barre A, Granier M, Fontanaud P, Chazalon M, Carmignac D, Robinson IC, Low MJ, Plesnila N, Hodson DJ, Mollard P, Méry PF. Somatostatin triggers rhythmic electrical firing in hypothalamic GHRH neurons. Sci Rep.2016 Apr 13;6:24394. doi: 10.1038/srep24394. PubMed PMID: 27072430; PubMed Central PMCID: PMC4829871.

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David J. Hodson, Islet Biology Lab, University of Birmingham, Institute of Metabolism and Systems Research, Centre for Endocrinology, Diabetes and Metabolism