Research in the Islet Biology Lab (or HodSquad) tackles challenging questions concerning the regulation of hormone release from pancreatic islets in health and disease. The major aims of the group are to develop novel tools and imaging approaches to understand how alpha, beta and delta cells, which reside within the islet, release hormone to maintain normal glucose. Importantly, we use tissue from individuals with type 1 and type 2 diabetes, as well as animal models, to understand what goes wrong in relevant pathologies. The group is highly inter-disciplinary, and with colleagues in Europe and North America, we combine chemistry, biology and genetics to open up new avenues of exploration in islet biology. The lab is not afraid of taking on difficult research questions or working outside of its comfort zone. While we consider ourselves a ‘jack of all trades, master of none’, it is always fulfilling when projects come together and individuals exceed their abilities!
INTERROGATION OF IMMATURE β-CELL FUNCTION
ENGINEERING OF SUPER-RESOLUTION LABELS TO VISUALISE THE DYNAMICS OF ENDOGENOUS GPCRs INVOLVED IN GUT HORMONE SIGNALLING
SPECIFIC TARGETING OF CELL AND RECEPTOR POPULATIONS WITH TETHERED PHARMACOLOGY
UNDERSTANDING HOW THE ACTIN CYTOSKELETON CONTRIBUTES TO α-CELL FUNCTION
The overarching aim of our research is to identify new mechanisms to preserve insulin, glucagon and somatostatin release during type 1 and type 2 diabetes, as well as improve the robustness of stem cell-derived islet-like structure